λ -Prophage induction modeled as a cooperative failure mode of lytic repression

Nicholas Chia, Ido Golding, Nigel Goldenfeld

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We analyze a system-level model for lytic repression of λ phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultraviolet radiation are in good agreement with experimental data.

Original languageEnglish (US)
Article number030901
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume80
Issue number3
DOIs
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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