α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

K. J. Klos, J. E. Ahlskog, K. A. Josephs, H. Apaydin, J. E. Parisi, B. F. Boeve, M. W. DeLucia, D. W. Dickson

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

Original languageEnglish (US)
Pages (from-to)1100-1102
Number of pages3
JournalNeurology
Volume66
Issue number7
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Clinical Neurology

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