We report haplotype analysis of the α-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the α-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.
|Original language||English (US)|
|Number of pages||5|
|Journal||Human molecular genetics|
|State||Published - Aug 15 2001|
ASJC Scopus subject areas
- Molecular Biology