TY - JOUR
T1 - α-Synuclein and the lewy body disorders
AU - Dickson, Dennis W.
PY - 2001
Y1 - 2001
N2 - α-Synuclein has risen to prominence during the past 5 years because of its association with several neurodegenerative diseases that have come to be known as the synucleinopathies. The clinical phenotype of the synucleinopathies is variable, with the most common being parkinsonism, autonomic dysfunction, and dementia. Progress has been made in clinical, neuropathologic and biochemical characterization of the synucleinopathies and their differentiation from other neurodegenerative disorders. At the molecular level, the synucleinopathies have conformational and post-translational modifications of synuclein that favor its fibrillization and aggregation in inclusions in neurons and gila. Whether inclusion body formation is an adaptive response or is directly related to degeneration of neuronal and glial cells is a topic of current research.
AB - α-Synuclein has risen to prominence during the past 5 years because of its association with several neurodegenerative diseases that have come to be known as the synucleinopathies. The clinical phenotype of the synucleinopathies is variable, with the most common being parkinsonism, autonomic dysfunction, and dementia. Progress has been made in clinical, neuropathologic and biochemical characterization of the synucleinopathies and their differentiation from other neurodegenerative disorders. At the molecular level, the synucleinopathies have conformational and post-translational modifications of synuclein that favor its fibrillization and aggregation in inclusions in neurons and gila. Whether inclusion body formation is an adaptive response or is directly related to degeneration of neuronal and glial cells is a topic of current research.
UR - http://www.scopus.com/inward/record.url?scp=84940364788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940364788&partnerID=8YFLogxK
U2 - 10.1097/00019052-200108000-00001
DO - 10.1097/00019052-200108000-00001
M3 - Review article
C2 - 11470957
AN - SCOPUS:84940364788
SN - 1350-7540
VL - 14
SP - 423
EP - 432
JO - Current opinion in neurology
JF - Current opinion in neurology
IS - 4
ER -