α-Synuclein and the lewy body disorders

Research output: Contribution to journalReview article

143 Scopus citations

Abstract

α-Synuclein has risen to prominence during the past 5 years because of its association with several neurodegenerative diseases that have come to be known as the synucleinopathies. The clinical phenotype of the synucleinopathies is variable, with the most common being parkinsonism, autonomic dysfunction, and dementia. Progress has been made in clinical, neuropathologic and biochemical characterization of the synucleinopathies and their differentiation from other neurodegenerative disorders. At the molecular level, the synucleinopathies have conformational and post-translational modifications of synuclein that favor its fibrillization and aggregation in inclusions in neurons and gila. Whether inclusion body formation is an adaptive response or is directly related to degeneration of neuronal and glial cells is a topic of current research.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalCurrent opinion in neurology
Volume14
Issue number4
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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