α-Blocker Use Is Associated With Decreased Risk of Sexual Dysfunction

Rajeev Kumar, Ajay Nehra, Debra J. Jacobson, Michaela E. McGree, Naomi M Gades, Michael M. Lieber, Steven J. Jacobsen, Jennifer St. Sauver

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: To examine the association between α-blocker use and sexual dysfunction among men participating in a population-based cohort of men residing in Olmsted County, MN. Lower urinary tract symptoms (LUTS) in men have previously been associated with sexual dysfunction. The use of α-adrenergic receptor blocking agents results in an improvement in LUTS for many men. If sexual dysfunction and LUTS share a common etiology, α-blocker use might also be associated with a decreased risk of sexual dysfunction. Methods: White men, aged 40-79 years, were randomly selected in 1990 and assessed for α-blocker use and LUTS severity. Sexual function was assessed using the Brief Male Sexual Function Inventory. Men who used α-blockers before any sexual dysfunction were considered "exposed." Hazard ratios and 95% confidence intervals were estimated separately for each sexual function domain using Cox proportional hazard models. Results: Of the 1724 men with a regular sexual partner included in the present study (mean age 57.74 years), 263 (15.3%) reported α-blocker use. α-Blocker use was associated with a decreased risk of sexual dysfunction across all domains for men ≥50 years old (age-adjusted hazard ratio 0.53-0.69). A decreased risk of erectile dysfunction and low libido remained significant only among those using α-blockers who also experienced an improvement in LUTS (P = .01). Conclusions: The use of α-blockers for LUTS was associated with a decreased risk of sexual dysfunction. Improvement in sexual function correlated with the improvement in LUTS more strongly among those using α-blockers.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalUrology
Volume74
Issue number1
DOIs
StatePublished - Jul 2009

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Lower Urinary Tract Symptoms
Libido
Adrenergic Antagonists
Sexual Partners
Erectile Dysfunction
Proportional Hazards Models
Adrenergic Receptors
Confidence Intervals
Equipment and Supplies
Population

ASJC Scopus subject areas

  • Urology

Cite this

α-Blocker Use Is Associated With Decreased Risk of Sexual Dysfunction. / Kumar, Rajeev; Nehra, Ajay; Jacobson, Debra J.; McGree, Michaela E.; Gades, Naomi M; Lieber, Michael M.; Jacobsen, Steven J.; St. Sauver, Jennifer.

In: Urology, Vol. 74, No. 1, 07.2009, p. 82-87.

Research output: Contribution to journalArticle

Kumar, R, Nehra, A, Jacobson, DJ, McGree, ME, Gades, NM, Lieber, MM, Jacobsen, SJ & St. Sauver, J 2009, 'α-Blocker Use Is Associated With Decreased Risk of Sexual Dysfunction', Urology, vol. 74, no. 1, pp. 82-87. https://doi.org/10.1016/j.urology.2008.12.080
Kumar, Rajeev ; Nehra, Ajay ; Jacobson, Debra J. ; McGree, Michaela E. ; Gades, Naomi M ; Lieber, Michael M. ; Jacobsen, Steven J. ; St. Sauver, Jennifer. / α-Blocker Use Is Associated With Decreased Risk of Sexual Dysfunction. In: Urology. 2009 ; Vol. 74, No. 1. pp. 82-87.
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