α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

K. J. Klos; J. E. Ahlskog; K. A. Josephs; H. Apaydin; J. E. Parisi; B. F. Boeve; M. W. DeLucia; D. W. Dickson

doi:10.1212/01.wnl.0000204179.88955.fa

α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

K. J. Klos, J. E. Ahlskog, K. A. Josephs, H. Apaydin, J. E. Parisi, B. F. Boeve, M. W. DeLucia, D. W. Dickson

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Abstract

The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

Original language	English (US)
Pages (from-to)	1100-1102
Number of pages	3
Journal	Neurology
Volume	66
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000204179.88955.fa
State	Published - Apr 2006

ASJC Scopus subject areas

Clinical Neurology

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title = "α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals",

abstract = "The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.",

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AU - Josephs, K. A.

AU - Apaydin, H.

AU - Parisi, J. E.

AU - Boeve, B. F.

AU - DeLucia, M. W.

AU - Dickson, D. W.

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AB - The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

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α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

Abstract

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