α-synuclein gene haplotypes are associated with Parkinson's disease

Matt Farrer; Demetrius M. Maraganore; Paul Lockhart; Andrew Singleton; T. G. Lesnick; Mariza De Andrade; Andrew West; Rohan De Silva; John Hardy; Dena Hernandez

α-synuclein gene haplotypes are associated with Parkinson's disease

Matt Farrer, Demetrius M. Maraganore, Paul Lockhart, Andrew Singleton, T. G. Lesnick, Mariza De Andrade, Andrew West, Rohan De Silva, John Hardy, Dena Hernandez

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

298 Scopus citations

Abstract

We report haplotype analysis of the α-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the α-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

Original language	English (US)
Pages (from-to)	1847-1851
Number of pages	5
Journal	Human molecular genetics
Volume	10
Issue number	17
State	Published - Aug 15 2001

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

Cite this

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title = "α-synuclein gene haplotypes are associated with Parkinson's disease",

abstract = "We report haplotype analysis of the α-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the α-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.",

author = "Matt Farrer and Maraganore, {Demetrius M.} and Paul Lockhart and Andrew Singleton and Lesnick, {T. G.} and {De Andrade}, Mariza and Andrew West and {De Silva}, Rohan and John Hardy and Dena Hernandez",

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T1 - α-synuclein gene haplotypes are associated with Parkinson's disease

AU - Farrer, Matt

AU - Maraganore, Demetrius M.

AU - Lockhart, Paul

AU - Singleton, Andrew

AU - Lesnick, T. G.

AU - De Andrade, Mariza

AU - West, Andrew

AU - De Silva, Rohan

AU - Hardy, John

AU - Hernandez, Dena

PY - 2001/8/15

Y1 - 2001/8/15

N2 - We report haplotype analysis of the α-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the α-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

AB - We report haplotype analysis of the α-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the α-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

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M3 - Article

C2 - 11532993

AN - SCOPUS:0035880458

SN - 0964-6906

VL - 10

SP - 1847

EP - 1851

JO - Human molecular genetics

JF - Human molecular genetics

IS - 17

ER -

α-synuclein gene haplotypes are associated with Parkinson's disease

Abstract

ASJC Scopus subject areas

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