Project: Research project

Project Details


DESCRIPTION (provided by applicant): Viscoelastic properties of tissues are
closely related to the tissue state and pathology. Vibro-acoustography (VA)
is new imaging method developed in our laboratory that produces a display of
the dynamic response of tissue to a vibrating force at a selected low
frequency (kHz range). Such images may be used for evaluation of tissue
A vibro-acoustography system uses the radiation force of ultrasound to produce
a highly concentrated oscillating force that vibrates the object at each
point. Object response is recorded by a hydrophone and used to produce the
image. The result is a speckle-free, transverse view, representing the
dynamic response of the object to the vibrating force. In preliminary in
vitro experiments, we have shown that vibro-acoustography can be used to image
hard materials such as calcifications inside human arteries, very small
particles such as micron-size microcalcifications in human breast tissue, and
lesions in liver. VA can also be used to image and evaluate the integrity of
prosthetic heart valves.
The purpose of this proposal is to develop a vibro-acoustogrraphy system with
a contact probe for in vivo applications. The goal of this research will be
achieved in two phases. The first phase consists of computer simulation of
the system. The second phase focuses on system implementation. The aims of
the first phase include: system design, modeling, and evaluating system
performance. The aims of the second phase include design and construction of
the ultrasound probe, design and construction of system electronics
(transmitter, receiver, and monitor), and evaluating and optimizing system
performance. Successful completion of this research will result in a new
class of noninvasive imaging and tissue evaluation device, which will provide
information about the mechanical properties of tissue that are not available
from other imaging modalities.
Effective start/end date8/1/027/31/08


  • Engineering(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)