Utility of memantine in preventing cognitive dysfunction in children receiving cranial radiotherapy

Project: Research project

Project Details

Description

PROJECT NARRATIVE Memantine is a drug used for adult dementia patients that has been shown to decrease the changes in thinking and memory that occur after whole brain radiotherapy in adults with brain metastasis. Based on the mechanism of action and animal models we expect memantine will be effective and safe for reducing short and long-term changes in brain function for children receiving radiation for brain tumors. Reduction of specific brain volumes after radiotherapy are associated with memory and thinking changes and we also hypothesize that neuroprotection with memantine will result in a reduction in volume loss in critical regions of the brain.
StatusActive
Effective start/end date9/18/1912/31/22

Funding

  • National Cancer Institute: $892,392.00

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