Project Details
Description
Project Narrative
Alzheimer’s disease (AD) is the leading cause of late-onset dementia affecting a large population of our
aging society, yet we still do not have an effective way to treat this devastating disease. Towards this, the goal
of this project is to understand the molecular etiology of AD by studying a strong genetic risk factor TREM2
which modulates microglial functions and immune responses in the brain. In vivo mouse models and in vitro
iPSC cellular models will be used to collectively address the dynamic effects of TREM2-mediated molecular
pathways to both inform disease mechanisms and suggest treatment strategies.
Status | Active |
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Effective start/end date | 2/1/20 → 12/31/22 |
Funding
- National Institute on Aging: $1,498,349.00
- National Institute on Aging: $667,900.00
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