Project: Research project

Project Details


DESCRIPTION: (Applicant's Description)

This proposal is being submitted as part of a cooperative agreement with
other members of the New Approaches to Brain Tumor Therapy (NABTT)
Consortium (Project Leaders: Henry Brem, M.D. and Stewart Grossman, M.D.;
Coordinating Center, Johns Hopkins University), in order to design and
conduct Phase I and Phase II treatment protocols for patients with
anaplastic gliomas. The primary objective of this proposal is to improve
the outcome for adult patients with primary brain tumors. We propose to
address this goal by combining our clinical investigative strengths with
those of the other members of the NABTT Consortium (Brown University,
Columbia University, Emory University, H. Lee Moffitt Cancer Center, Henry
Ford Hospital, Johns Hopkins University, Massachusetts General Hospital,
Northwestern University, Wake Forest University, Washington University,
University of Alabama at Birmingham, University of Pennsylvania, and
University of Texas at San Antonio). The particular strengths that our
institution brings to the NABTT Consortium include: 1) a large number of
patients with primary brain tumors and a well-developed referral network, 2)
a brain tumor-dedicated multidisciplinary clinical team that has been in
place for over ten years, 3) extensive clinical and laboratory resources, 4)
a significant number of NIH-supported brain tumor laboratory research
programs, including a recently-awarded Brain Tumor Program P r oject Grant
(P01 NS34856, Steven Rosenfeld, M.D., Ph.D., Principal Investigator), as
well as a number of industrial-academia contacts for support of
neuro-oncology research on campus, and 5) nationally-recognized expertise in
cancer research, including biostatistics and data management, in the
clinical pharmacology of cancer therapeutics, in functional neuroimaging,
and in the conducting of institutional and cooperative Phase I and II
clinical trials. This proposal thus builds on our extensive clinical
investigative expertise within the context of a well established
multi-institutional brain tumor treatment consortium.
StatusNot started


  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute: $109,192.00
  • National Cancer Institute: $115,840.00
  • National Cancer Institute: $112,467.00
  • National Cancer Institute: $118,933.00


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