Therapeutic ECM Resorption in Cellular Systems and Precision Cut Lung Slices.

Project: Research project

Project Details

Description

Project Narrative Idiopathic Pulmonary Fibrosis is characterized by progressive scarring of the lung, but how the lung normally reverses scarring to functionally repair tissue is not well understood. The proposed studies will establish robust models in which to study extracellular matrix deposition, the defining characteristic of scarring, and its degradation and resorption. The proposed models will use both primary human fibroblasts and ex vivo tissues cultured from the lungs of individuals with IPF, providing new insight into the failure of scar resorption in IPF, and new targets through which to promote this critical process.
StatusActive
Effective start/end date12/15/2011/30/22

Funding

  • National Heart, Lung, and Blood Institute: $486,834.00

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