Project: Research project

Project Details


DESCRIPTION: (Applicant's Description)

Adenocarcinoma of the large bowel continues to be a significant public
health problem, ranking second as a cause of death due to cancer and
representing 10 percent of all cancers. Early detection is now recognized
as one of the most important factors in colorectal cancer prognosis.
Currently available screening modalities that facilitate early detection are
either very costly for general population screening (colonoscopy) or have
low sensitivity and specificity for disease detection (fecal occult blood
testing). To significantly impact colorectal cancer mortality rates, tools
are needed that improve the ability to know which members of the population
merit aggressive screening, or alternatively, tools are needed that are cost
effective yet highly sensitive, such as tests that detect precancerous
genetic alterations in colonocytes shed in stool. A promising strategy to
move toward these goals is that of studying families that have had increased
rates of colorectal cancer. These families, along with carefully selected
controls, will permit examination of the genetic and environmental factors
predisposing to colorectal cancer. Although significant progress has been
made in identifying the uncommon, high penetrance genes in hereditary colon
cancers, the identification of low penetrance genes or environmental factors
that may account for the majority of familial colorectal cancer will require
studies of large numbers of carefully ascertained families. In response to
the National Cancer Institute's call for a Cooperative Family Registry for
Epidemiologic Studies of Colon Cancer, the applicant proposes a process
whereby 5,000 colorectal cancer probands will be surveyed for family
history, and from this group 500 high risk families will be selected for
further recruitment. Family recruitment for the registry will involve
collection of clinical and epidemiologic data, plus collection of biologic
specimens including blood and tumor. Similar ascertainment will be
undertaken for both case-matched controls and colorectal cancer population
controls. Tumor specimens from both cases and controls will be
characterized with respect to expression of mismatch repair proteins as
determined by immunohistochemistry. This application is for collaborative
development of a durable resource that will provide high quality data and
biologic materials to the most promising research efforts directed toward
decreasing colorectal cancer mortality.
Effective start/end date9/17/978/31/13


  • National Cancer Institute: $1,277,837.00
  • National Cancer Institute: $1,321,718.00
  • National Cancer Institute: $18,800.00
  • National Cancer Institute: $222,055.00
  • National Cancer Institute: $1,304,966.00
  • National Cancer Institute: $1,153,640.00


  • Medicine(all)


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