Targeting Cellular Senescence to Extend Healthspan

Project: Research project

Project Details


OVERALL – PROJECT NARRATIVE Khosla/Kirkland Cellular senescence is known to drive a number of aging co-morbidities. In this proposal, we will test the Geroscience Hypothesis that targeting this fundamental aging mechanism will delay, prevent, or alleviate multiple age-related disorders, including metabolic dysfunction, skeletal fragility, vascular dysfunction and frailty. If successful, the proposed studies will set the stage for pilot studies in humans using drugs that either reduce the burden of senescent cells, or modulate their inflammatory properties, to simultaneously slow or prevent multiple age-associated diseases.
Effective start/end date6/1/191/31/23


  • National Institute on Aging: $2,841,000.00
  • National Institute on Aging: $2,551,899.00
  • National Institute on Aging: $397,500.00


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