Project: Research project

Project Details


DESCRIPTION (Adapted from Applicant's Abstract): This project addresses the
clinical applications of functional magnetic resonance imaging (fMRI) to
neurosurgical planning, particularly for brain tumors and epileptic foci.
If aggressive surgical resection of a tumor or other structural lesion
located in or near functionally eloquent cortex is considered, then
localization of functional areas relative to the surgical target must be
ascertained in order to avoid a postoperative neurological deficit. This is
particularly critical for aggressive resection of brain tumors because
normal cortical landmarks are distorted by the tumor mass. The need to
avoid functionally critical areas is particularly critical in patients whose
only symptom is epilepsy. Such patients tend to have benign or indolent
non-life-threatening lesions, and a postoperative neurological deficit may
represent an unacceptable surgical risk. Traditional methods of
neurosurgical functional cortical brain mapping require surgical exposure of
the brain surface before any functional information is obtained. FMRI, on
the other hand, is non-invasive, can be performed on an out-patient basis,
and is performed before any commitment to perform a neurosurgical procedure
has been made. Despite these potential advantages implementation of fMRI in
surgical planning has been impeded in large measure by motion artifacts.
The effect of inter-image head motion on an fMRI time series is twofold: 1)
to mask the detection of pixels which undergo true positive physiological
activation, and 2) to create areas of spurious or false positive activation
which are due to stimulus correlated head motion. Aim #1 of this proposal
is concerned with the development and testing of real-time correction of
image to image bulk head motion during fMRI. Aim #2 will test the
hypothesis that real-time correction techniques improve the fidelity of fMRI
sensorimotor mapping in volunteer subjects. Aim #3 will test the same
hypothesis in neurosurgical patients who later undergo surgical functional
brain mapping. The applicants believe that prospective correction using
navigator and orbital navigator echoes is the most rational solution to the
problem of head motion in fMRI both when applied to surgical planning and in
other studies of brain function.
StatusNot started


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