• Lupu, Ruth (PI)
  • Kern, Francis (PI)
  • Soonmyoung, Pai (PI)
  • Byers, Stephen (PI)
  • Ziff, Barbara (PI)
  • Mazumder, Amitabha (PI)
  • Russell, Kathy (PI)
  • Trock, Bruce (PI)
  • Wellstein, Anton (PI)
  • Clarke, Robert (PI)
  • Honig, Susan (PI)
  • Dickson, Robert B. (PI)
  • Ziff, Barbara (PI)
  • Trock, Bruce (PI)
  • Swain, Sandra (PI)
  • Honig, Susan Flamm (PI)
  • Delap, Robert (PI)
  • Lippman, Marc (PI)
  • Soonmyoung, Pai (PI)
  • Byers, Stephen (PI)
  • Mazumder, Amitabha (PI)
  • Russell, Kathy (PI)
  • Wellstein, Anton (PI)
  • Clarke, Robert (PI)
  • Dickson, Robert B. (PI)

Project: Research project

Project Details


This document describes our SPORE application entitled "Novel Targets for
Prevention and Therapy of Breast Cancer". This program is based on the
premise that molecules involved in the mitogenic, invasive and metastatic
behavior of breast cancer as well as escape from hormone independence are
identifiable and thus can be exploited for improved prognostication,
therapy selection, and design of specific biologic therapies for treatment
and prevention of disease. In this application a series of interactive
research projects are focused on expanding our understanding of the
pathogenetic significance of these molecules in breast cancer progression
and exploiting this information to develop effective new strategies for
breast cancer prevention and treatment. Specific targets chosen for
translational research studies include heparin binding growth factors
required for tumor induced angiogenesis (and thus critical in conversion
from in situ to invasive breast cancer); a novel metalloproteinase secreted
by breast cancer cells; newly discovered ligands of erbB2 which may play a
role in breast cancer progression and therapy resistance, and the estrogen
receptor. Preclinical and clinical studies of prognostic factors and
therapies involving these breast cancer products are developed. A series
of four novel cores is described including a tumor bank of fresh and frozen
breast tumor materials, a repository of breast cancer cell lines, clinical
breast cancer research resources and a unique mechanism of research
coordination which support these projects and foster interaction with other
institutional strengths and other SPOREs. A program for continued
development of faculty committed to breast cancer research is described
with specific examples of young faculty and their work which will benefit
from this program. A portfolio of high priority pilot projects together
with a system for prioritization and oversight is discussed which
contribute directly to major SPORE projects and translational research
activities. Finally, a coherent, tightly structured organization for the
SPORE is described which provides accountability, flexibility and optimal
interaction within the SPORE, within the institutional structure, and with
other SPOREs to achieve the goal of improved outlook for women at risk of
breast cancer and for patients already suffering from the disease.
Effective start/end date9/30/928/31/05


  • Medicine(all)