SIGNIFICANCE OF CHROMOSOME 7 ALTERATIONS IN GLIAL TUMORS

  • Jenkins, Robert Brian (PI)
  • Feuerstein, Burt (PI)
  • Yates, Allen (PI)
  • James, Charles David (PI)
  • Mamrak, Sandra (PI)

Project: Research project

Project Details

Description

DESCRIPTION: (provided by Applicant) Gliomas are an important clinical
problem. Prognostic variables include histology (cell type and grade), age,
and performance status. Unfortunately, the histology of gliomas is not
simple, and pathologists often disagree in their diagnosis. Since diagnosis
is an important parameter in patient selection for clinical trials, studies
may suffer from entry criteria that are not objective, and comparisons across
studies that target these tumors are therefore unreliable. Furthermore, since
cases in the community are treated according to these diagnoses, optimal
therapy may not ever reach a particular patient. We and others have found
that chromosome aberrations occur commonly in these tumors and a pilot study
has suggested that some of them are prognostic. This proposal seeks to
validate this finding and to determine more particular regions on chromosomes
responsible for this behavior. The aims are: 1) Define the minimum
recurrent 7q amplicon in grade 3 astrocytomas. 2) Functional
characterization of genomic sequence spanning critical region defined in aim
1. 3) Determine whether copy number aberrations (CNAs) and/or small genetic
elements on chromosomes 7, 10, 4q, and 12q predict survival in grade 2 and 3
astrocytoma patients.
StatusFinished
Effective start/end date6/14/015/31/06

Funding

  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute: $93,964.00
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute: $1,839,107.00
  • National Cancer Institute: $126,453.00
  • National Cancer Institute
  • National Cancer Institute: $123,187.00
  • National Cancer Institute: $1,939,449.00
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute: $1,878,726.00
  • National Cancer Institute
  • National Cancer Institute

ASJC

  • Medicine(all)

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