PROJECT NARRATIVE Age is the primary risk factor for cognitive decline, and with the growing aging population, the number of people with Alzheimer’s disease and related dementias may triple to 14 million by 2050 with no effective solutions on the horizon. Although it is well-known that age-related cerebrovascular dysfunction is a major contributor to cognitive decline, targetable mechanisms responsible for this relationship are unknown. The proposed work will interrogate whether and how cellular senescence, a central aging mechanism that is effectively targeted by genetic and pharmacological agents, mediates cerbrovascular dysfunction underlying cognitive decline and thus, may reveal an intuitive, vital new strategy for treatment or prevention of dementia.
|Effective start/end date||1/1/21 → 12/31/22|
- National Institute on Aging: $224,103.00
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