Role of Nuclear Pore-Regulated Mechanisms in Prostate Cancer Aggressiveness

Project: Research project

Project Details


PROJECT NARRATIVE Tumor cells display nuclear pore and chromosomal defects, however, their specific mechanistic contribution to cancer progression is ill-defined. To enable the dissection of these intricate biological processes and their contribution to the aggressiveness of prostate cancer, our laboratory interrogates in vitro and in vivo patient- derived experimental models via transcriptomic, high-resolution live imaging microscopy, biochemistry and genetic approaches combined with publicly available patient datasets evaluation and patient tumor tissue validation. Our studies aim to identify novel actionable nuclear pore-regulated mechanisms in lethal prostate cancer that may benefit the clinical management of therapy refractory disease.
Effective start/end date12/1/1911/30/22


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