Role of ICAM1 in development and progression of pancreatic cancer

PROJECT NARRATIVE The crosstalk between KRas mutations and inflammatory processes drive the development and progression of pancreatic cancer. Here we will investigate the mechanisms of how oncogenic KRas mediates the attraction of macrophages and how this contributes to development of cancer, but also test novel approaches to block this event. Overall our project will lead to preclinical data supporting new treatment strategies that can be incorporated into standard of care treatment and may lead to a better outcome for patients with advanced cancer.