• Litchy, William J (PI)
  • Stevens, John (PI)
  • Muenter, Manfred (PI)
  • Lucas, Alexander (PI)
  • Laws, Edward (PI)
  • Stonnington, Henry (PI)
  • Kurland, Leonard (PI)

Project: Research project

Project Details


Existing knowledge about neurologic conditions has been greatly
enhanced by studies from Olmsted County, Minnesota, a
naturally-occurring epidemiological experiment. This
"community laboratory" is due to a) the relatively stable
population, b) the accessibility of medical records since early in
this century, and c) the limited number of health care providers
in the area. Twenty years of intensive effort by the Principal
Investigator have resulted in a facility which supports
descriptive and analytic studies in the neurosciences.

We now seek funding to continue the productively and
applicability of this unique resource. This request for renewal of
the Neuroepidemiology Program Project includes proposals
covering 14 distinct topics in neurology. The studies will be a)
descriptive in nature, providing incidence, prevalence, mortality
and survivorship data; b) analytic in design, being either
hypothesis-generating or hypothesis-testing or both; and c) of
medicolegal and economic interest, with application to health
care utilization issues. New efforts will include descriptive data
for mental retardation, cervical radiculopathy, brain injury,
trigeminal and glossopharyngeal neuralgia, and childhood spinal
muscular atrophy. Case-control studies of carpal tunnel
syndrome, Bell's palsy, cerebral palsy, mental retardation, brain
tumors, and anorexia nervosa are proposed. Studies with other
applications include the examination of the incidence rates and
trends of neurosurgical and otolaryngological procedures, and
etiologic and survivorship aspects of cerebral palsy. The
medicolegal aspects of neurologic conditions necessitate reliable
and valid epidemiologic data; estimates of the current burden, to
the individual and to society, of neurologic illness and subsequent
disability, require accurate data on the frequency, nature and
severity of these conditions. Previous experience attests to the
unparalleled contribution, in this respect, of studies from the
Rochester Epidemiology Program Project (REPP) records-linkage
Effective start/end date12/1/8110/31/92


  • Medicine(all)
  • Neuroscience(all)