RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITY

Project: Research project

Project Details

Description

DESCRIPTION: This is a study of genetic and environmental determinants of
venous thromboembolism (VTE) in the Rochester Minnesota Olmsted County
population. The specific aims of the study are: 1) to update the 1966-95
inception cohort to include Olmsted County residents with VTE during the five
year period, 1996-2000; 2) to extend the analysis of risk factors for VTE by
identifying two Olmsted County residents (controls) without VTE matched by age
and gender to each definite or probable case within the 1996-2000 cohort, and
to obtain plasma and genomic DNA from all cases and controls and perform a
case-control study to test the hypothesis that first specific diseases are
related to VTE and mutations of the factor five and prothrombin are independent
risk factors for VTE in the community; and interactions between environmental
and genetic factors. They will determine the population attributable risk for
VTE associated with each risk factor, both individually and collectively for
all significant risk factors. They will then compare two Olmsted County
residents who received major surgery without developing VTE matched by date and
type of surgery to a case with VTE within three months after surgery in order
to look at risk factors related to surgery and genetic markers. They will do a
similar analysis this time using two Olmsted County residents who were
hospitalized for medical illness without developing VTE matched by gender and
date of hospitalization to a case who developed VTE within three months after
hospitalization and perform a case-control study to test the hypothesis again
that risk factors and genetic markers are associated with elevation of risk of
VTE. Finally, the investigators will plan to extend their analysis of current
VTE in relationship to use of standard heparin and low molecular weight
heparin.
StatusFinished
Effective start/end date4/1/015/31/20

Funding

  • National Heart, Lung, and Blood Institute: $694,655.00
  • National Heart, Lung, and Blood Institute: $694,657.00
  • National Heart, Lung, and Blood Institute: $694,657.00
  • National Heart, Lung, and Blood Institute: $694,654.00

ASJC

  • Medicine(all)

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