• Hubmayr, Rolf Dieter (PI)
  • Rehder, K.A.I. (PI)
  • vanhoutte, Paul (PI)
  • Wilson, Theodore (PI)
  • Gillespie, Delmar (PI)
  • De Troyer, Andre (PI)
  • Hyatt, Robert (PI)
  • Rehder, K.A.I. (PI)
  • Rodarte, Joseph (PI)

Project: Research project

Project Details


This Program Project combines the disciplines of engineering
mechanics, physiology, pharmacology, anesthesiology, medicine and
critical care to study the mechanical behavior of the respiratory
system in health and disease. Combined experimental and modeling
approaches address the mechanics of the chest wall including the
interaction of thorax and abdomen, the mechanics of the diaphragm,
the mechanical properties of the lung parenchyma, and the
determinants of regional ventilation. Unique new methodology is
employed which determines diaphragmatic shape, displacement and
regional contraction. The respiratory actions of muscles and their
integration in the process of respiration are examined. These
studies will contribute to the development of specific and
objective tests for diaphragmatic fatigue in man which can be used
to evaluate less invasive ways of assessing the balance between
mechanical load and endurance of the respiratory muscles in
patients with respiratory failure. They should also lead to more
rational care of such patients. In vitro studies examine the control of airway and pulmonary
vascular smooth muscle with particular emphasis on the modulating
influence of the epithelium and on interactions between the two
components. These studies will be extended to animal models of
reactive airway disease. Other related studies elucidate the
mechanisms of changes in airway resistance produced by anesthetic
agents and other drugs used in surgery. These studies are not only
of great clinical importance but may explain apparently conflicting
results in the literature on airway reactivity in which different
anesthetic regimens have been employed.
Effective start/end date9/30/7711/30/92


  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)


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