Regulation of Nutrient Homeostasis by COMMD proteins

Nutrient handling is dependent on transport mechanisms across the intestine and the cellular plasma membrane. This process is carried out by membrane proteins that are constantly moving between the cell surface and other intracellular locations, such as the endosomal network. The studies proposed here seek to uncover the molecular mode of action of newly discovered cellular proteins that regulate the movement of nutrient transporters between the plasma membrane and the endosome, and assess their impact on nutrition in living animals