REGULATION OF HEPATIC FIBROGENEISS BY TANGO1

Project: Research project

Project Details

Description

PROJECT NARRATIVE Liver cirrhosis develops in response to continued injury to the liver, which increases the formation of scar tissue. An important part of scar tissue is collagen I which is made by liver cells. Treatments aimed at disrupting collagen I incorporation into scar tissue have had limited success in treating liver fibrosis, leading us to study how liver cells produce and release collagen I. The goal of our research is to understand how collagen I is moved so that new treatments can target this process and thereby limit collagen I release and scar tissue formation.
StatusActive
Effective start/end date2/5/1812/31/22

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases: $675,836.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $162,214.00

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