Project: Research project

Project Details


The proposed research will examine whether differences in regional
adipose tissue fatty acid metabolism are present in humans. We have
shown that upper body obesity in women is associated with increased FFA
availability, and that the excess release can be localized to
non-splanchnic, upper body adipose tissue. Excess FFA release is thought
to result in some of the metabolic consequences of upper body obesity,
especially if FFA are released directly into the portal circulation
(i.e., from visceral adipose tissue) where they may have more exaggerated
effects on hepatic glucose, insulin and lipid metabolism. Surprisingly,
we were unable to document increased splanchnic FFA release in healthy
upper body obese women. The proposed studies will determine whether
increased hepatic FFA delivery is present in humans with
noninsulin-dependent diabetes mellitus (NIDDM)/hypertriglyceridemia,
whether gender specific differences are present in the regional
regulation of adipose tissue FFA release, and whether there are regional
differences in meal triglyceride fatty acid storage between men and women
and between obese individuals with different body fat distributions.
Specifically, these studies will 1) determine whether hepatic FFA
delivery is increased in NIDDM/hypertriglyceridemic individuals (obese
and non-obese) compared with glucose tolerant, normal lipidemic
individuals (obese and non-obese); 2) net splanchnic FFA release in
visceral upper body obesity is greater than that observed in subcutaneous
upper body obesity; 3) regional differences in adipose tissue FFA release
are present in non-obese men and women; 4) mixed beta-, alpha-adrenergic
stimulation results in differential increases in regional adipose tissue
FFA release compared with pure beta-adrenergic stimulation; 5)
physiologic hyperinsulinemia results in equal suppression of regional
adipose tissue FFA release in non-obese men and women; 6) regional
storage of exogenous triglyceride fatty acids is similar following a
"bolus" meal and during a continuous enteral meal infusion in non-obese
men and women; and 7) differences in regional triglyceride fatty acid
storage from exogenous sources are associated with differences in body
fat distribution in obese women before and after weight loss. These
studies will provide new insights into the regulation of regional
lipolysis in health and disease and will aid in the understanding of
adipose tissue fatty acid storage and release in obese and non-obese men
and women. It is hoped that this information will aid in the development
of more disease specific therapy for obesity and related conditions.
Effective start/end date9/30/928/31/19


  • Medicine(all)