Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Clinical Centers (CC) (U01).

Project: Research project

Description

DESCRIPTION (provided by applicant): Project Summary: Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics (PVDOMICS). Pulmonary Vascular Disease (PVD) is a poorly understood but lethal condition. Currently, pulmonary hypertension (PH) is nosologically divided into Groups associated with primary vascular abnormalities, left-sided heart failure, pulmonary parenchymal and thromboembolic diseases. It is likely that these different forms of PH share common mechanistic pathways leading to PVD that might be targeted therapeutically, but currently these ostensible shared mechanisms remain poorly understood. In order to better understand the fundamental mechanisms of PVD in PH, this application seeks to enroll large numbers of people with each form of PH and perform detailed phenotyping of clinical, hemodynamic, functional, biomarker, metabolomic, and proteomic patterns.
StatusFinished
Effective start/end date9/15/147/31/19

Funding

  • National Institutes of Health: $239,370.00
  • National Institutes of Health: $319,532.00
  • National Institutes of Health: $314,738.00

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Vascular Diseases
Pulmonary Hypertension
Lung Diseases
Metabolomics
Proteomics
Blood Vessels
Heart Failure
Biomarkers
Hemodynamics
Lung