Project: Research project

Project Details


DESCRIPTION (Adapted from Applicant's Abstract): The broad objective of
this project is to increase the efficacy of vascular diagnosis by magnetic
resonance imaging (MRI). The specific goal is to develop rapid magnetic
resonance angiography (MRA) encoding techniques that are robust for flow
patterns with spatially and temporally varying motion. These encoding
techniques will be employed in sequences which create vessel contrast via
either of two mechanisms: 1) inflow enhancement, also called time-of-flight
(ToF) contrast, and 2) T1-weighted contrast, used in conjunction with
intra-vascular injection of a T1 shortening contrast agent
(contrast-enhanced). Applications will be in the carotid arteries and
peripheral vasculature, although improvements in pulse sequence design may
well be useful in other MRA and non-MRA applications.

The first two years of this project will involve implementation,
characterization, and optimization of two encoding methods.The first method
is spiral scanning and reconstruction for in-plane encoding. The second
method, which is the more unique and important part of this grant, is
localized quadratic (LQ) encoding with a shifted modulation transfer
function (MTF) for through-plane encoding. The combination of these two
encoding techniques will serve as the basis for sequence development. The
final three years will be used for further sequence development and initial
in-vivo studies on normal volunteers and clinical patients.

The sequences will be specifically compared to current techniques to assess
the following properties: 1) reduction in imaging time, 2) reduction of
motion artifacts, 3) reduction of flow voids, and 4) reduction of oblique
flow artifact. It is hypothesized that the sequences can achieve all of
these improvements with respect to current techniques for both ToF and
contrast-enhanced MRA.
StatusNot started