• Strand, Edythe (PI)
  • Braun, Allen (PI)
  • Braun, A. (PI)
  • Manuel, Don (PI)
  • Wayland, Sarah (PI)
  • Braun, A. (PI)

Project: Research project

Project Details


DESCRIPTION: (Adapted from the Applicant's Abstract.) The major long-term
objective of this proposal is to combine three ABR techniques that will
help to delineate objectively and quantitatively the relationship between
ABRs and peripheral hearing loss. This combination of techniques will
allow evaluation of ABRs initiated from specific regions of the cochlea,
specify error rates of threshold measures, reduce the variability of
response parameter measurements, and optimize clinical test time. The
three ABR techniques to be combined are a masking one for measuring the
cochlear-place specific ABRs, a statistical one for objectively defining
ABR threshold based on response properties rather than visual
interpretation, and a weighted averaging one based on Bayesian principles
using estimates of the background noise. A second long-term objective is
to find an independent ABR threshold measure that can be used
simultaneously with the above combinations to improve detection rates
without compromising false-positive error rates. The third long-term
objective is to develop these techniques to run on a micro-computer-based
system to facilitate widespread clinical use. Six specific aims of the proposed research focus on evaluating normal and
hearing-impaired patients with the combination of techniques, delineating
the effects of stimulus parameters, evaluating methods to minimize the
noise in the averages, and evaluating the joint use of other independent
objective ABR measures to improve detection. The proposed work may fill critical, unmet needs in the current clinical
use of ABRs for diagnostic information by providing a better understanding
of the complex relationship between perceptual and electrophysiological
measures in hearing-impaired patients, maximizing the averaging efficiency,
and developing a truly objective, quantitative and consistent ABR method
for estimating the audiogram and measuring response parameters.
Effective start/end date4/1/90 → …


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $86,940.00
  • National Institutes of Health: $86,940.00
  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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