PRIOR BLOOD TRANSFUSION AS A CANCER RISK FACTOR

Project: Research project

Project Details

Description

DESCRIPTION: (Applicant's Description) This proposal seeks five years of
funding to develop research and teaching skills in cancer epidemiology and
to undertake laboratory training in molecular pathology methods which can be
applied to cancer epidemiology studies. I have recently finished a joint
M.D.-Ph.D. degree from the University of Iowa, with a Ph.D. degree in
epidemiology. I have completed postdoctoral training in cancer epidemiology
at the University of Minnesota and in Aging at the University of Iowa. I am
currently an Assistant Professor of Epidemiology, tenure track, in the
Department of Preventive Medicine and Environmental Health at the University
of Iowa.

The goal of my research plan is to acquire new skills in molecular pathology
and clinical immunology which can be applied to my cancer epidemiology
studies. I will focus my attention on the possible role of blood
transfusions in the carcinogenic process. With this grant, I will attempt
to replicate and expand my work on prior blood transfusion as a cancer risk
factor by analyzing three previously collected case-control studies and an
ongoing prospective cohort study. I also plan to develop a nested
case-control study assessing transfusion history and lymphoma risk using the
Agricultural Health Study cohort.

In order to assess whether any transfusion and cancer risk association is
confounded by the indication for the transfusion, I will conduct a pilot
study of battle-injured Vietnam veterans which will lay the groundwork for
studying whether blood transfusion for a non-specific- indication (i.e.,
trauma) is related to cancer risk. In order to address potential mechanisms
underlying the putative association, I will use molecular pathology
techniques to study whether the Epstein-Barr virus has an etiologic role in
the transfusion and lymphoma association and whether Cytomegalovirus has an
etiologic role in the transfusion and kidney cancer association. I will
also design and conduct a pilot study to assess the immunological
consequences that a blood transfusion has for an immunocompetent host.

My other professional goals during this grant include the development of
teaching skills in cancer epidemiology and experience in helping manage a
cancer registry. To accomplish these goals, I will work in consultation
with senior faculty members from the Departments of Preventive Medicine and
Environmental Health, Pathology, and Internal Medicine and from the Cancer
Center at the University of Iowa.
StatusNot started

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