• Jaffe, Allan S (PI)
  • Ehsani, Ali (PI)
  • Ter-Pogossian, Michel (PI)
  • Gross, Richard (PI)
  • Cain, Michael (PI)
  • Markham, Joanne (PI)
  • Lange, Louis (PI)
  • Saffitz, Jeffrey (PI)
  • Needleman, Philip (PI)
  • Ludbrook, Philip (PI)
  • Strauss, Arnold (PI)
  • Corr, Peter (PI)
  • Miller, James (PI)
  • Sobel, Burton (PI)

Project: Research project

Project Details


This multidisciplinary investigation of the pathogenesis, progression, and
favorable modification of ischemic heart disease involves 27 investigators from
13 departments engaged in 11 research projects and 5 cores laboratories.
Coronary vascular pathogenetic mechanisms are the focus of studies of
attenuation of ultrasound, contractile properties, and prostaglandin metabolism
in normal and diseased vessels. Improved quantification of regional myocardial
ischemia and infarction are being pursued by delineation of processes governing
release and disappearance of biochemical markers of necrosis (MB and
mitochondrial CK) and the distribution of positron-emitting tracers detected by
computer reconstruction tomography. Etiological roles of amphipathic lipids and
regional adrenergic stimulation in the genesis of malignant dysrhythmia and of
calcium flux in the precipitation of cell death in myocardium and the
microvasculature will be characterized to provide a basis for more effective
prophylaxis and therapy. Clinical projects are devoted to improved detection of
regional myocardial ischemia and infarction with positron tomography;
characterization of early recurrent infarction and identification of the roles
of implicated etiological factors such as platelets and coronary vasospasm with
enzymatic, scintigraphic, and tomographic approaches; and identification of
biochemical and physiological determinants of early and late dysrhythmia
including the extent of initial infarction and prevailing concentrations of
circulating amphipathic lipids in patients at rest and with exercise. Studies
involve several levels of biological organization including isolated cells,
vessels and myocardium in vitro, isolated perfused hearts, experimental animal
preparations, and patients. Although the scope is broad, the techniques
required have been implemented, verified, and in several cases developed during
the initial grant interval with each project therefore predicated on a
substantial base of information already acquired.
Effective start/end date9/30/8412/31/95


  • National Heart, Lung, and Blood Institute


  • Medicine(all)


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