Pneumocystis carinii: Macrophage & Epithelial Activation

Project: Research project

Project Details

Description

PROJECT NARRATIVE: Pneumocystis pneumonia (PCP) remains a major cause of illness and death in patients with impaired CD4 lymphocytic immunity, particularly in patients with AIDS. Host C-Type Lectin Receptors (CLRs; Dectin-1 and Mincle) on macrophages and other lung cells interact with Pneumocystis and activate the central CARD9 signaling molecule initiating killing and clearance of Pneumocystis and triggering lung inflammatory responses, which are of particular importance in hosts lacking CD4 cell immunity. This proposal will evaluate how CARD9 and the related CLRs act to eliminate Pc organisms and regulate lung inflammatory responses during PCP, and how this system can be exploited for cell-based therapies given in addition to traditional antibiotic therapy for severe PCP.
StatusActive
Effective start/end date7/10/9812/31/22

Funding

  • National Heart, Lung, and Blood Institute: $239,405.00
  • National Heart, Lung, and Blood Institute: $292,000.00
  • National Heart, Lung, and Blood Institute: $292,000.00
  • National Heart, Lung, and Blood Institute: $292,000.00
  • National Heart, Lung, and Blood Institute: $244,018.00
  • National Heart, Lung, and Blood Institute: $234,924.00
  • National Heart, Lung, and Blood Institute: $6,434,014.00
  • National Heart, Lung, and Blood Institute: $377,750.00
  • National Heart, Lung, and Blood Institute: $276,869.00
  • National Heart, Lung, and Blood Institute: $285,138.00

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