Project: Research project

Project Details


DESCRIPTION: This is a resubmission of a proposal addressing an
uncommon but devastating neurodegenerative disorder for which there is
currently no effective therapy; severe, steroid-unresponsive
demyelinating disease. Following dramatic success with plasma
exchange in their uncontrolled experience, the investigators propose
to conduct a double-blind, placebo controlled, crossover trial
comparing the efficacy of plasma exchange to sham plasma exchange in
22 patients treated at Mayo Clinic Rochester in the CRC. The study
will cover a three year period. The proposal is detailed and
thoughtful, reflecting the extensive experience of the investigators
with the clinical care of persons with severe demyelinating disease.
While the disorder to be studied is not common, it is devastating.
Demonstration of a beneficial treatment is therefore of great
significance. Plasmapheresis is an expensive therapy currently used in
many centers to treat severe demyelinating disease. If this treatment
is shown not to be beneficial, great savings may result.
StatusNot started


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