PHYSIOLOGY OF BONE METABOLISM IN AN AGING POPULATION

  • Spelsberg, Thomas C, (PI)
  • Monroe, David G (PI)
  • Oursler, Merry Jo (PI)
  • Khosla, Sundeep (PI)
  • Melton, III, L Joseph III, (PI)
  • Spelsberg, Thomas C, (PI)
  • Riggs, Lawrence B. (PI)
  • Melton, Joseph L. (PI)
  • Mann, Kenneth (PI)
  • O'Fallon, William (PI)
  • Riggs, B. Lawrence (PI)
  • Melton, Joseph (PI)
  • Ofallon, William M. (PI)
  • Melton, Joseph (PI)
  • Amin, Shreyasee (PI)
  • Melton, Joseph L. (PI)
  • Mann, Kenneth (PI)
  • Riggs, Lawrence B. (PI)
  • O'Fallon, William (PI)
  • Ofallon, William M. (PI)
  • Melton, Joseph (PI)
  • Lawrence Riggs, B. (PI)
  • Melton, Joseph (PI)
  • Melton, III, L Joseph III, (PI)

Project: Research project

Description

Osteoporosis is one of the most important diseases associated with aging
and is also one of the most important issues affecting women's health.
Fractures due to osteoporosis exact a staggering toll in disability and
expense. For a 50-yr-old white women, the lifetime risk of having one or
more fractures associated with osteoporosis is 40% to 50% and is about one-
third of this for white men or black women. Each year in the United
States, there are at least 1.3 million fractures due to osteoporosis, which
cost the healthcare system between $10 and $20 billion and, unless the
disease is controlled, these will double over the next 25 yrs because of
continued aging of the population. The long-range goal of this Program
Project is to understand better the causes of age-related bone loss in
osteoporosis an, by so doing, to develop effective strategies for its
treatment and prevention. The Program Project contains 4 independent
research components, each representing a different research discipline, and
an administrative and biostatistical core. "Pathophysiology of
Involutional Osteoporosis,' is the clinical investigative component. In
this project, normal women will be studied to understand better the two
most important causes of involutional bone loss -- estrogen deficiency and
age-related processes. Also, women with postmenopausal osteoporosis will
be studied to determine if their greater levels of bone turnover and rates
of bone loss are due to unique processes that differ substantially from
those in comparable women without osteoporosis. All studies will be made
in a metabolic ward and will combine traditional physiologic methods with
state-of-the-art techniques. "Record Studies of Hip Fractures," is the
epidemiology component. It features a series of unique population-based,
retrospective (noncurrent, historical) cohort studies designed to assess
the effects of certain diseases, drugs, and lifestyle differences on the
incidence of fractures. Also, secular changes in age-adjusted fracture
rates over the last 20 yrs will be assessed. "Regulation of Bone Cell
Function," is the basic science component. It uses cell biology and
molecular biology techniques to evaluate the effects of estrogen on the
differentiation and expression of growth factors on cultured normal
osteoblast-like cells derived from bone or bone marrow and on a unique new
cell line derived from normal undifferentiated fetal osteoblast-like cells
immortalized with a temperature sensitive/regulated SV-40 large T antigen.
Also, estrogen regulation of osteoblast-derived paracrine factors that
regulate osteoclastic activity will be identified and characterized.
"Preventive Therapy with Calcium," is an ongoing clinical trial, which will
require a 1-yr extension to complete. It is designed to determine if bone
loss in elderly women can be prevented or reduced by calcium
supplementation.
StatusActive
Effective start/end date9/1/844/30/20

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,673,729.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,682,810.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,646,669.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,670,607.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,607,046.00
  • National Institutes of Health
  • National Institutes of Health: $1,679,611.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,657,653.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,748,807.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,629,834.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,748,419.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,667,257.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,500,799.00
  • National Institutes of Health

Fingerprint

Bone and Bones
Osteoporosis
Estrogen Receptors
Osteoblasts
Steroids
Osteogenesis
Estrogen Receptor alpha
Intercellular Signaling Peptides and Proteins
Estrogens
Biostatistics
Osteoclasts
Nuclear Receptor Coactivator 1
Bone Resorption
Population
Estrogen Receptor beta
Hip Fractures
Carbon Monoxide
Nuclear Receptor Coactivator 2
Selective Estrogen Receptor Modulators
Knockout Mice

ASJC

  • Medicine(all)