PG545 synergizes with PARP inhibitors in ovarian cancer to disrupt DNA repair through modulation of DEK-RAD51 axis

  • Shridhar, Viji (PI)

Project: Research project

Project Details

Description

PROJECT NARRATIVE The goal in this application is to determine the efficacy of PG545 to synergize with PARP inhibitors in vivo using PDX models and in patient derived ascitic cells and to confirm whether the underlying mechanism by which PG545 downregulates RAD51 in ovarian cancer cells.
StatusActive
Effective start/end date2/1/221/31/23

Funding

  • National Cancer Institute: $185,831.00

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