PUBLIC HEALTH RELEVANCE STATEMENT We and others have shown that both abnormal brain changes and neuropsychiatric symptoms, such as depression and anxiety, are independent risk factors for cognitive decline. Here we propose to fol- low thousands of normal individuals older than 60 years who have undergone both brain imaging and neuropsychiatric assessment in order to determine who develops new-onset cognitive decline. Our results will help the field of Alzheimer's disease to understand the pathways linking abnormal brain changes, neuropsychiatric symptoms and the outcome of mild cognitive impairment or dementia.
|Effective start/end date||5/1/18 → 11/30/22|
- National Institute on Aging: $355,209.00
- National Institute on Aging: $431,163.00
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