Pathogenesis of Primary Biliary Cholangitis

Project: Research project

Project Details


PROJECT NARRATIVE We will conduct the first multi-omics translational study of primary biliary cholangitis (PBC), to improve understanding of the culprits driving this rare, autoimmune liver disease. By integrating multiple layers of omics data, we will better define the architecture of cellular networks driving PBC. In so doing, we will identify molecular signatures including immune alterations, environmental toxins, and metabolism-related chemicals unique to PBC patients, thereby spurring improved understanding of PBC pathobiology and identification of novel druggable targets.
Effective start/end date12/21/2011/30/22


  • National Institute of Diabetes and Digestive and Kidney Diseases: $628,683.00


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