Pathogenesis of infection in pancreatitis: from sterile inflammation to sepsis

Project: Research project

Project Details

Description

PROJECT NARRATIVE: Based on unregulated lipolysis by pancreatic lipases generating unbound fatty acids causing inflammatory cell damage, thus impairing pathogen clearance; we will study how sterile acute pancreatitis(AP) gets infected and septic using cell, animal models (Aim 2), along with human measurements to determine relevance (Aim 1).
StatusActive
Effective start/end date4/1/1912/31/22

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases: $415,825.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $517,630.00

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