Myosin II and Glioma Dispersion

Project: Research project

Project Details

Description

ABSTRACT
The propensity of glioma cells to invade brain is a vexing problem that limits the effectiveness of all
current therapies. Thus, there remains a pressing need to identify new anti-invasive strategies.
Accomplishing this will require a detailed understanding of how glioma cells migrate within the brain,
and what machinery they use to drive this process. In our earlier work, we determined that the
molecular motor myosin II plays an indispensable role in glioma dispersion through brain. However,
fundamental questions about this process remain unanswered. First, how do myosin IIA and IIB, the
two myosin II isoforms commonly expressed in gliomas, execute the processes underlying brain
invasion? Second, how do signal transduction pathways that are frequently dysregulated in gliomas
affect the functions of these myosin II isoforms and how redundant are these pathways in stimulating
myosin II-dependent tumor invasion? Finally, how do myosin IIA and IIB function contribute to the
dispersion of gliomas in tumor-bearing animals? The experiments described in this proposal will explore
the advantages and potential limitations of one anti-invasive approach that targets a key element in the
machinery gliomas use to invade brain--myosin II.
StatusNot started