Project: Research project

Project Details


We have recently successfully produced three-dimensional shaded
surface ultrasound images of the left ventricular chamber of a
human using a new method of transducer staqblization and rotation.
Daa for producing multidimensional volumetric images were acquired
by incrementally rotating a sector scanner transducer through 180%
about its central beam centered at an appropriate acousic window.
Fifty angles of view were recorded for subsequent selection by
gating with the ECG and respiration. Sctor scan images were then
selected from each view at appropriate points in the heart and
respiratory cycles and inserted into a three-dimensional volume.
The resulting imates promise new methods of analyzing complex
dynamic geometries of the heart and great vessels using advanced
workstation software. This proposal is a collaborative effort between one of the largest,
most experienced echo cardiography laboratories and an active,
widely knwon ultrasonic research laboratory. The Biodynamics
Research Unit, of which the Ultrasound Laboratory is a part, has
been developing multidimensional imaging devices (such as the
Dynamic Spatial Reconstructor) and software for more than 20 years.
One major result from this effort has been ANALYZE a widely used
Mayo-developed multidimensional data nalaysis package. It is this
vast experience in multidimensional software and pioneering efforts
in clinical echocardiography that provide the expertise for this
proposed reseach. The proposal consists of four aims. First, we will refine our
methods of multidimensional scanning by developing methods of
transducer stabilizaation, image synchronization, and image
digitization and storage (on digital cassette tape). Second, we
will evaluate the fidelity of the multidimensional images and
calculated parameters using data obtained from fresh fixed hearts
in a water tank, anesthetized animals (also scanned on the DSR),
and selected volunteers and patients. Third, we will develop
advanced software for cliniclly specific analysis and measurement
of myocardial structure and function from the ultrasound
vol.umetric data. Fourth, using ROC analysis, we will test the
accuracy and clinical usefulness of the data acquisition and
analysis workstation concept using specifically selected cardiac
lesions proven clinically or surgically in a large number of
Effective start/end date4/1/898/31/06


  • Medicine(all)