Project: Research project

Project Details


Stroke is among the leading causes of death and disability in
adults in the U.S. Over the past several decades, clinical studies have
identified many environmental risk factors for stroke such as hypertension,
diabetes mellitus and cigarette smoking. More recent evidence suggests that
genetic components also contribute to the risk of stroke as well. Growth in the
understanding of the human genome and advances in genetic epidemiology, make it
possible to clarify the genetic contributions to complex diseases such as
ischemic stroke. The overall long-term objective of this application is to
search for regions of interest in the human genome that may harbor stroke
susceptibility genes. The primary aim of the application is to collect DNA
samples from 300 sibling pairs concordant for ischemic stroke and to perform a
genome wide screen for genetic risk factors for ischemic stroke in these
individuals. The screen will employ microsatellite markers spaced at a maximum
of 20 centamorgan intervals. Secondary aims include: (1) identifying genetic
regions of interest associated with ischemic stroke in adults below age 50
years and (2) identifying genetic regions of interest that are independent of
stroke risk factors such as diabetes, hypertension, cigarette smoking, and
atrial fibrillation. Probands will be screened for sibs concordant for stroke
from patients with acute ischemic stroke who present to hospitals that are
participating in the NIH-sponsored trial comparing carotid angioplasty/stenting
to endarterectomy (CREST RO1-NS38384-01). A centralized stroke verification
committee will assure and accuracy in stroke phenotyping. DNA banking will be
done to permitted future collaborative efforts to study the genetic basis for
stroke risk.
Effective start/end date9/30/0012/31/11


  • Medicine(all)
  • Neuroscience(all)