Project: Research project

Project Details


This application will serve as the foundation on which the PI will build
a major line of research dedicated to the area of alcohol and nicotine
dependence treatment. Alcohol dependent smokers are at high risk for
tobacco-related morbidity and mortality. Effective interventions are
needed to reduce smoking prevalence in this population. Among smokers,
a history of major depression has been identified as a major obstacle
to smoking cessation. Individuals with a history of alcohol dependence
and major depression may represent a population of especially treatment-
resistant smokers. This new investigator proposal builds on our
previous work and focuses on treatment of smokers with a history of both
alcohol dependence and major depression. The theoretical framework on
which this program of research is based is the social learning
cognitive-behavioral model of relapse which emphasizes the role of
situational variables and coping responses in addiction relapse. Our
preliminary work suggests that a mood management intervention, designed
to enhance coping with negative affect, may improve smoking outcomes for
smokers with a history of alcohol dependence and depression. The first
primary aim of this study is to evaluate the efficacy of a mood
management intervention on 12-month smoking outcomes for 144 adult,
abstinent alcoholic smokers with a history of major depression. A
further aim is to examine mechanisms and processes of change associated
with smoking treatment outcomes. The second primary aim is to examine
the effect of the smoking treatments on alcohol abstinence and to
identify factors associated with smoking and alcohol outcomes. The
ultimate goal of this work is to develop effective interventions which
will reduce tobacco-related morbidity and mortality in this high-risk
population without adversely affecting alcohol outcomes. A randomized,
two-group design will be used to evaluate the added benefit of a mood
management intervention compared to a state-of-the-art smoking cessation
treatment. The two conditions are: 1) Transdermal Nicotine Therapy and
Behavioral Counseling (BC) and 2)BC plus Cognitive-Behavioral Mood
Management Training (MM). Treatment will consist of 8 weekly group
sessions. The major assessments will occur at end-of-treatment (week
8), and 1,3,6,and 12-month follow-up. Dependent measures include 7-day
point prevalence smoking abstinence verified with expired air carbon
monoxide and alcohol and drug abstinence verified with breathalyzer,
urine drug screen and informant report.
StatusNot started


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.