PROJECT NARRATIVE Biliary fibrosis is a process of peri-portal scarring within the liver that is caused by diseased bile ducts and often progresses to end stage liver disease. Currently, liver transplantation is the only effective treatment for end-stage liver disease. However, due to a severe shortage of donor organs, many patients die awaiting liver transplantation. Thus, it is necessary to understand the mechanisms regulating biliary fibrosis and to identify pathways that can be targeted therapeutically. This proposal will focus on understanding how epigenetic dysregulation in bile duct cells (cholangiocytes) leads to the release of paracrine molecules that subsequently activate hepatic stellate cells. In particular, the project will identify the specific signaling events and epigenetic complexes that drive fibrogenic gene expression in cholangiocytes. These efforts are designed to identify new molecular targets that can be regulated to more effectively treat patients.
|Effective start/end date||2/15/19 → 1/31/23|
- National Institute of Diabetes and Digestive and Kidney Diseases: $321,975.00
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