Molecular basis of PGP9.5 overexpression in lung cancer

  • Jen, Jin, (PI)

Project: Research project

Description

We have previously identified that PGP9.5 is frequently overexpressed in lung cancers. We have also used yeast two-hybrid assay to identify genes that interact with PGP9.5. We recently showed that three genes, JAB1, UBC9 and RanBPM, are associated with PGP9.5 both in vitro and in vivo. Site-directed mutagenesis method is being used to determine the regions of PGP9.5 protein that interact with these factors. We are also also in the process of developing a mouse model that allows for tissue specific expression of PGP.5 in the small airway of the lung to determine the role of PGP9.5 in lung tumorigenesis.
StatusNot started

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $281,260.00
  • National Institutes of Health: $283,529.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Lung Neoplasms
Gene Expression
Lung
Carcinogenesis
Genes
Genetically Modified Animals
Neoplasms
Transforming Growth Factor beta
Two-Hybrid System Techniques
Transgenic Mice
Animal Models
Site-Directed Mutagenesis
Transgenes
Small Interfering RNA
Cell Survival
Epithelium
Growth
Proteins
Cell Proliferation
Neoplasm Genes

ASJC

  • Medicine(all)