METHODS TO PREVENT POST-SMOKING CESSATION WEIGHT GAIN

  • Leischow, Scott J, (PI)

Project: Research project

Project Details

Description

The weight gain that most smokers experience following smoking cessation is
not only an annoyance, but may increase the likelihood of smoking relapse
in some individuals. However, very little research exists on optimal
methods of preventing post-cessation weight gain, and, when weight gain
occurs, who is most likely to relapse. The purpose of this project is to
assess the clinical efficacy of nicotine replacement therapy and dietary
management in the prevention of post-smoking cessation weight gain, and to
prospectively assess the impact of weight gain on smoking relapse. The
studies here proposed will be carried out in the context of a group smoking
cessation program and we will manipulate specific treatment components in
order to assess their influence on weight gain and smoking relapse. In experimental #1, we will randomly assign subjects to receive on a fixed
schedule (q1h) either standard 2 mg or placebo (.5 mg) nicotine polacrilex
(Nicorette) while withdrawal, dietary intake, weight gain, and psychosocial
variables are assessed. This study should provide valuable information on
the efficacy of nicotine replacement on post-cessation weight gain, dietary
intake, and relapse rates. In addition, if nicotine replacement does
prevent post-cessation weight gain, we will be able to assess whether
nicotine replacement simply postpones the weight gain, since we propose
assessing dietary intake for a year following the completion of nicotine
replacement. In experiment #2, all subjects will be assigned to receive
and use 2 mg nicotine polacrilex on the same fixed schedule as in
experiment #1; however, just prior to their caloric intake in order to
prevent weight gain after the cessation of nicotine replacement. The other
half will receive no such training and will continue to eat ad lib. As in
study #1, we will assess dietary intake in all subjects through the one
year follow-up visit. This study will provide valuable information on the
effects of dietary restriction on postcessation weight gain, withdrawal,
and smoking relapse - as well as provide new data on the likelihood of
compliance with a restricted diet following smoking cessation. The proposed studies should provide new and important information about the
prevention of post-smoking cessation weight gain and the effects of weight
gain on smoking relapse. In addition, the results of these studies should
add to our understanding of the mechanisms contributing to post-cessation
weight gain - particularly with regard to nicotine replacement and dietary
intake. Finally, the results of this research should have direct
applicability in smoking cessation programs: (1) they will be useful in
the development of optimal clinical strategies for preventing postcessation
weight gain and (2) because the methods employed in these studies are
currently commercially available, they will be generalizable to medical
practice as well as specific smoking treatment clinics.
StatusFinished
Effective start/end date9/30/908/31/94

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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