MECHANISMS OF GROWTH CONTROL BY STEROIDS

Project: Research project

Description

This proposed program project focuses upon regulation of cell proliferation
by steroid hormones. Three projects are proposed that deal with different
aspects of the manner in which glucocorticoids, estrogens, and sterols
regulate proliferation. Although the projects deal almost entirely with
malignant cells, the phenomena to be investigated have direct relevance to
regulatory processes that are common to growth control in both transformed
and normal cells. The central hypothesis to be explored proposes that
these compounds play a critical role in the neoplastic transformation and
maintenance of the proliferative state. The individual projects address
regulation of human lymphoid cells by oxysterols and glucocorticoids
(Projects I and II) and mechanisms of estrogen induction of renal tumors in
hamster kidneys (Project III).
StatusFinished
Effective start/end date3/4/912/28/94

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $412,281.00
  • National Institutes of Health
  • National Institutes of Health: $514,652.00

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Oncogenes
Glucocorticoids
steroids
glucocorticoids
Cell Proliferation
cells
Cell Line
Dexamethasone
binding proteins
Lymphoma
Fibroblasts
clones
Genes
estrogens
Gene Transfer Techniques
receptors
human cell lines
Thymidine Kinase
DNA
kidneys

ASJC

  • Medicine(all)