Mechanisms of Clinical and Hemodynamic Response to Pulmonary Vasodilator Therapy in Fontan physiology

Project: Research project

Project Details

Description

PROJECT NARRATIVE
The proposed research is relevant to public health because identification of the mechanism by which
pulmonary vasodilators improve organ function in people with prior Fontan operation, will help inform improved
prevention and early treatment strategies for end-organ dysfunction, which in turn, will save lives, reduce
morbidity, and reduce healthcare costs. Successful completion of the proposed research in this application will
provide evidence-based proof of principle for future clinical trials to determine the benefits of pulmonary
vasodilators patients with clinically proven pulmonary vascular disease based on pulmonary vascular reserve.
The proposed research is relevant to the NIH’s mission pertaining to the pursuit of knowledge to extend
healthy life and reduce the burdens of illness and disability.
StatusActive
Effective start/end date12/20/2111/30/22

Funding

  • National Heart, Lung, and Blood Institute: $632,301.00

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