LUNG/LUNG INTERACTIONS--SINGLE LUNG TRANSPLANTATION

  • Hubmayr, Rolf Dieter, (PI)

Project: Research project

Project Details

Description

It is our goal to determine the mechanisms of interaction between two
lungs of different sizes and mechanical properties. Our preliminary
observation that the distribution of inspired gas between an
emphysematous lung (E) and a normal lung (N) varies substantially with
the mode of breathing caused us to consider the implications of these
mechanisms for single lung transplantation. We will determine how lungs
of unequal sizes and mechanical properties deform the chest wall and will
characterize the consequences of this deformation on regional ventilation
and the function of the respiratory pump. Using biplane fluoroscopic
marker techniques, we will image the lungs and hemi-diaphragms of dogs
with unilateral papain-induced emphysema and test the following
hypotheses: (1) during mechanical ventilation at conventional rates, most
of the inspired gas is distributed to the E lung because it is more
compliant; (2) during spontaneous breathing, most of the inspired gas is
distributed to the N lung because the displacement of the hemi-diaphragm
which apposes the N lung is greater than the displacement of the
hemi-diaphragm which apposes the E lung; and (3) differences in shape and
preload (length of muscle fibers prior to activation) cause the
hemi-diaphragms to displace by different amounts. To relate displacement
to muscle mechanics, we will quantify all determinants of shortening,
which are intrinsic to the hemidiaphragms and consist of preload,
contractile state, and afterload. On the basis of these measurements, we
will determine if systematic differences in hemi-diaphragm lengths and
shortenings are consistent with uniform loads and neural activation.
StatusFinished
Effective start/end date7/13/926/30/96

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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