LRP1 and HSPG in cerebrovascular clearance of abeta

Project: Research project

Project Details


Beta-amyloid (also known as Abeta) is a protein fragment that accumulates into amyloid plaques in the brain, one of the hallmark features of Alzheimer's disease. Beta-amyloid is also found in healthy brains, and there is growing evidence that defects in the clearance of beta-amyloid from the brain may account for some forms of Alzheimer's disease. There are several biochemical pathways for clearance of beta-amyloid. One of these pathways involves binding of the protein fragment to the cell surface, followed by transport into the cell and degradation by cellular machinery.

Effective start/end date1/1/12 → …


  • Alzheimer’s Association


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