LOCALIZATION OF SUSCEPTIBILITY LOCI IN PROSTATE CANCER

Project: Research project

Project Details

Description

DESCRIPTION (Adapted from the Investigator's Abstract): This application by
Stephen N. Thibodeau entitled "Localization of susceptibility loci in
prostate cancer" seeks funding to support a three-part study to identify
genes responsible for prostate cancer predisposition. The study proposes a
genome-wide search by microsatellite polymorphism in families with three or
four members affected by prostate cancer. These families have been
ascertained from the Mayo Clinic Registry of Radical Prostatectomy,
comprising approximately 5,500 men who were treated with radical
prostatectomy since 1967. As a result of initial evaluation of this
registry, 60 kindreds with three or more living affected men (200 sib pairs)
have been identified so far as potential subjects for this study. Initial
screening by full genome analysis using markers separated by approximately
10 centimorgans will be conducted. Data will be analyzed by both
conventional parametric linkage analysis and by affected sib pair
approaches. Regions of the genome harboring known or suspected candidate
genes for familial prostate cancer or those regions showing elevated LOH in
prostate tumor progression (as determined in preliminary studies by the
applicant and by other published studies) will be targeted first. Regions
identified as potential candidates will be evaluated more closely by refined
linkage mapping using additional markers from the region, by physical
mapping, and by positional cloning within the regions of interest.
Candidate genes within these regions will ultimately be evaluated using
conventional approaches for candidate gene analysis.
StatusFinished
Effective start/end date12/26/9611/30/07

ASJC

  • Medicine(all)